Research & Trials
LEAN Project: Weight Loss and Appetite Suppression
The primary aim is to examine whether the intake of PhosphoLEAN is effective in aiding a cohort of women in losing weight. Participants taking the supplement will have significantly greater ... › More
Weight Loss Maintenance in Primary Care (PrimaryCare)
After a three month weight loss phase involving the use of meal replacements, participants are randomised into different weight loss maintenance conditions. Aim 1: ... › More
Influence of Weight Loss or Exercise on Cartilage in Obese Knee Osteoarthritis Patients (CAROT)
Obesity and osteoarthritis (OA) co-exist in an increasing part of the population.The two diseases intertwine in several ways. The evolution in the population shows a tendency towards ... › More
Incisionless Treatment for Patients With Inadequate Weight Loss Following Roux-en-Y Gastric Bypass
It is estimated that up to 20% of patients who have Roux-en-Y Gastric Bypass (RYGB) surgery will not meet their weight loss goal, or may even regain some of the weight they initially lost. One ... › More
Randomised Study of a Simple Weight Loss Program for Obese Patients With Obstructive Sleep Apnoea
The purpose of the study is to determine if weight loss interventions aimed at lifestyle modification (dietary education, food diary pedometer) result in weight loss in patients with mild-moderate ... › More
Can a Physical Activity Skill Development and Parent-Centered Dietary Intervention Help Combat Child Obesity?
The purpose of this study, and its original contribution to research, is to determine the impact of a physical activity skill development and parent centered family weight management program on the ... › More
Evaluating the Effectiveness of Financial Incentives in Promoting Weight Loss Among Obese Individuals
Obesity is a major cause of premature aging and the second leading cause of preventable mortality in the United States, accounting for approximately 110,000 deaths per year. Financial incentives ... › More
Glycemic Load, Weight Loss and Cardiovascular Disease Risk
To investigate the hypothesis that reducing the glycemic load of the diet will improve changes in body composition and cardio-vascular risk factors. The study compares a conventional reduced-fat, ... › More
Study to Assess If Internet-Based Tailored Advice Could Modify Behaviour to Improve Health
The purpose of this trial is to find out if a special website might help people discover if they have high cholesterol and then enable them to manage their cholesterol more appropriately. The primary ... › More
SMOOTH - Blood Pressure Control in Diabetic/Obese Patients
The primary objective of the SMOOTH study was to demonstrate that, when combined with hydrochlorothiazide (12.5 mg), telmisartan (80 mg) is at least as effective and possibly superior to valsartan ... › More
CAROLINA: Cardiovascular Outcome Study of Linagliptin versus Glimepiride in Patients with Type 2 Diabetes
The aim of the study is to investigate the long-term impact on cardiovascular morbidity and mortality, relevant efficacy parameters (e.g., glycaemic parameters) and safety (e.g., weight and ... › More
Safety, Tolerability and Pharmacokinetics of Multiple Doses of ZGN-433 in Obese Female Volunteers
The purpose of this study is to assess whether multiple doses of ZGN-433 is safe and well tolerated in obese female subjects. The study will also provide information on how much ZGN-433 gets into the ... › More
Energy Expenditure & Activity During & After Exercise-Induced Weight Loss
This project is aimed at determining whether an exercise-based weight loss intervention causes compensation in some component of energy expenditure such that the increase in measured energy ... › More
High Fat Diet II on Weight Loss (HFD)
To evaluate two different diets and their effects on weight loss and measurements of several risk factors for cardiovascular disease. One diet will be a high saturated fat diet (HSFD) and the other ... › More
Physical Activity Following Surgery Induced Weight Loss
The primary objective of this study will be to determine the effects of physical activity in patients during substantial surgery-induced weight loss. A randomised controlled physical activity ... › More
Comparison of Two Workplace-Sponsored Obesity Prevention Programs (The WAY [Worksite Activities for You] to Health Study)
Obesity has reached epidemic proportions in the United States with nearly 64% of American adults considered overweight or obese. Weight loss programs that take place at work have proven to be ... › More
Growth Hormone as a Determinant of Weight Regulation
With the alarming increase in the prevalence of obesity, identifying factors that predispose individuals to weight-gain is of critical importance. Even when caloric intake and physical activity ... › More
Ezetimibe/Simvastatin in Patients With Metabolic Syndrome
A 6-week clinical trial in patients with metabolic syndrome and hypercholesterolemia at high risk for coronary heart disease to study the effects of ezetimibe/simvastatin and atorvastatin on lipids.
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Leisure Time Activity and Nutrition Program (LEAN)
The purpose of this investigation is to conduct an 8-week pilot study to examine the effects of two different leisure-time activity prescriptions on dietary intake, leisure-time activities, and ... › More
High Density Lipoprotein Turnover
The objective of the study is to evaluate the effect of Rimonabant 20mg in comparison to placebo, on HDL and VLDL lipoprotein kinetics, over a 12 months period.
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