Uncovering side effects before a drug hits the market
Side effects are a major reason that drugs are taken off the market and a major reason why patients stop taking their medications, but scientists are now reporting the development of a new way to predict those adverse reactions ahead of time. The report on the method, which could save patients from severe side effects and save drug companies time and money, appears in ACS’ Journal of Chemical Information and Modeling.
Yoshihiro Yamanishi and colleagues explain that drug side effects are a major health problem — the fourth-leading cause of death in the U.S. — which by some estimates claim 100,000 lives every year. Serious side effects are the main reason why existing drugs must be removed from the market and why pharmaceutical companies halt development of new drugs after investing millions of dollars. Current methods of testing for side effects are costly and inaccurate. That’s why the scientists sought to develop a new computer-based approach to predicting possible side effects.
They show the usefulness of their proposed method on simultaneous prediction of 969 side effects of 658 drugs that already are in wide medical use. The method is based on knowledge about chemical and biological information about ingredients in these medications. They also used the approach to identify possible side effects for many uncharacterised molecules. Based on that work, the scientists conclude that the new method could be helpful in uncovering serious side effects early in the development and testing of new drugs, avoiding costly investment in medications unsuitable for marketing.
Article Date: 21/1/2013
- Side Effects Of Cholesterol-lowering Drugs
- New Blood Transplant Method Stops Fatal Side Effect, Stanford Study Finds
- Diabetes drug's healthy side effect
- Side effects predict success of breast cancer treatment
- Online medicine side effects register open to all Australians
Rate this article
List News by Medical Area
Australia’s leading source for trustworthy medical information written by health professionals.
Please be aware that we do not give advice on your individual medical condition,
Parenting information is available at Parenthub.com.au
|^ Back to Top|