Medical Dictionary
Galactorrhea
| Galactorrhea is where there is abnormal milk secretions from the breast. Both genders may be affected and may be a side effect of some medications such as antipsychotics. |
Galactosemia
| Galactosemia is a rare genetic metabolic disorder which affects proper metabolism of the sugar galactose. |
Gallbladder
| The gallbladder is a pear shaped gastrointestinal organ situated just below the liver. The gallbladder's main function is the storage and concentration of bile. Bile is a yellow-green substance that helps break down fats in the intestines. |
Gallstones/ Gall Stones
| Gallstones are solid "stones" which are formed within the gallbladder, an organ that stores bile excreted from the liver. Bile is made up of water, salts, lecithin, cholesterol, and other substances. If the concentration of the components changes, gallstones may form. Gallstones may be small or large, depending on how long they have been forming. |
Gamete
Sex cells, that is the cells which can be fertilised by gametes of the opposite sex. In females gametes are known as eggs, oocytes or ovum. In males gametes are known as sperm or spermatozoa. More on male reproductive system. More on female reproductive system. More on sperm analysis. |
Gamete Intra-Fallopian Transfer (GIFT)
Gamete intra-fallopian transfer (GIFT) is the transfer of viable oocytes and sperm into the fallopian tubes for fertilisation. |
Gametes
| Gametes refer to the reproductive cells, i.e. cells from males (sperm) and females (eggs) which have the capacity to fertilise/be fertilised. |
Gamma Amino Butyric Acid (GABA)
| Gamma amino-butyric acid or GABA is an inhibitory neurotransmitter (chemical messenger) found in the brain. |
gangrene
| Gangrene refers to the decay and death of tissue resulting from an interruption in blood flow to a certain area of your body. |
Gardasil
| Gardasil is a vaccine that prevents diseases caused by Human Papillomavirus (HPV) types 6, 11, 16 and 18. These include:
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Gardeners syndrome
| Gardener's syndrome involves the development of multiple tumors in soft and hard tissues of the body. |
Gardner's Syndrome
| Autosomal dominant variant of familial adenomatous polyposis, caused by mutations in the APC gene. Features include multiple premalignant colon polyps, benign bone exostoses, epidermal cysts, dermoid tumours, fibromas and neurofibromas. Onset: around 20 years of age. |
Gastric
| Gastric means of or pertaining to the stomach. |
Gastric banding
| Gastric banding is a common type of surgery for weight loss. It is usually performed laparoscopically (via key-hole surgery). Gastric banding involves placing an adjustable silicone band around the stomach. This acts similarly to a tight belt and reduces the capacity of the stomach. Reductions in meal sizes can lead to weight loss. |
Gastric bypass
| Gastric bypass is a type of surgery for weight loss which may be used to treat obesity. during the procedure a small pouch is created in the stomach which is connected to further along the small intestine. (refer to anatomy and physiology of the gastrointestinal system for further information). Food can thus bypass or divert away from parts of the stomach and intestines. This reduces absorption of fats and calories (causing weight loss) but can also lead to reduced absorption of important nutirents (malnutrition). |
Gastric Tube
A gastric tube is a tube inserted into the stomach to feed patients who cannot take food through their mouths. |
Gastric Ulcers
| A Gastric Ulcer is a break in the tissue lining the stomach. The term 'peptic ulcer' refers to those that occur in either the stomach or the first part of the small intestine that leads out of the stomach, called the duodenum. It was once commonly thought that stress, smoking and diet were the principal causes of stomach ulcers. |
Gastrointestinal
Gastrointestinal means pertaining to the stomach or intestinal systems. For more information, see the Gastrointestinal System. |
Gastrointestinal Lesions
Gastrointestinal lesions are wounds, ulcers or tissue damage occurring in the stomach. |
Gastrointestinal Stromal Tumour
Gastrointestinal stromal tumour is a cancerous tumour of the gastrointestinal tract. |
Gastro-oesophageal reflux disease
| Gastro-oesophageal reflux disease (also known as gastroesophageal reflux disease, GORD, GERD or acid reflux disease) is a disease of the lower oesophagus and stomach. It involves the inflammation of the lower oesophagus due to the reflux of gastric juice and/or bile. |
Gastroparesis
| Gastroparesis; also known as delayed gastric emptying, results in food being in the stomach for much longer than normal. It is caused by muscle or nerve damage and results in symptoms such as bloating and belching. |
Gastroplasty
| Gastroplasty (also known as gastric stapling) is a surgical procedure for weight loss. It basically involves stapling the stomach to form a small pouch. This reduces the amount of food that can be taken into the stomach and eventually leads to loss of weight. |
Gastroscopy
Gastroscopy is endoscopic investigation of the upper gastrointestional tract. See Oesophagogastroduodenoscopy (OGD). |
Gastrulation
| Gastrulation is a process of cell migration through which the flat two layered embryo becomes a flat three layered embryo. |
Gate control theory
| The gate control theory is a theory explaining how pain is produced and experienced by the body. This theory suggests that pain is stimulated by noxious (harmful) stimuli at nerve endings. However, the body has a "gate" which it can "shut" to stop the flow of these noxious stimuli and hence stop the sensation of pain. By stimulating nerves it is possible to artificially cause this "gate" to close and hence stop the sensation of pain in the stimulated regions. |
Gating
| Gating, in relation to pain, is a normal regulatory mechanism which affects the way we perceive pain. In the spinal cord, normal (non-pain) sensory fibres are linked to pain fibres in such a way that one can suppress the other. For example, after stubbing your toe (a painful stimulus), gently rubbing the skin over the toe (non-pain sensation) can reduce the feeling of pain. The non-pain sensation takes over and inhibits the transmission of the pain sensation. |
Gaucher disease
Gaucher disease is a lysosomal storage disorder that is autosomal recessive and is characterised by a deficiency in the lysosomal enzyme glucocerebrosidase that is required in the breakdown of the glycolipid glucocerebroside (glucosylceramide). More information on Gaucher disease. |
Gelclair
Gelclair is a medical device used to reduce pain in patients with oral mucositis or other conditions that cause damage to the mucous membranes of the mouth. It is administered as a solution which is rinsed in the mouth. The solution adheres to the gums, tongue and other mucous membranes, creating a physical barrier that protects the damaged membranes from irritation. For more information, see Gelclair. |
Gene
| A gene is the master instruction that describes to a cell how to make a particular molecule. Since our entire body is made up of molecules of one kind or another, genes can have very profound effects on what our body does and how it does it. A gene is stored in the cell using a substance called DNA. People get their genes from a mixing of their parents' genes. Genes even describe how to make the cells reading the genes - this sounds very confusing, even impossible! However, the body solves it by starting life with special cell called an egg, which comes with some of the reading equipment ready-made. |
Gene Sequence
| A gene sequence is a stretch of DNA in a specific location on a chromosome that codes for a gene. |
Gene therapy
Gene therapy involves the alteration of DNA to correct or prevent disease by inserting a gene artificially into the genome of an organism to correct a genetic defect. |
General Anaesthesia
| General Anaesthesia: This is a type of anaesthesia in which a patient feels nothing due to drugs called 'general anaesthetics'. In a conscious state, the brain constantly receives information from nerves throughout the body - these drugs stop the brain from properly understanding these signals, and so they cause a state of unconsciousness. When these drugs wear off, consciousness returns. While anaesthetised, a patient can be given other drugs to relax muscles, manage pain, and control the patient's condition. A general anaesthetic is given by a specialist doctor called an anaesthetist, who monitors the patient's condition while they are unconscious. |
Generalise
| In psychotherapy when clients are said to effectively generalise this is referring to their ability to adapt what they have learnt in their psychotherapy sessins to different settings, situations and people other than their psychologist. How well the client can generalise their new behaviours, skills and thoughts is the best indicator of psychotherapeutic effectiveness. |
Generic Medication (Generic Drug)
A generic drug is a copy of the original branded drug. Once the patent for the original product has run out, the pharmaceutical company who developed the branded drug no longer has the exclusive right to produce and distribute the medication, and other pharmaceutical companies are able to create their own version. The generic drug uses the same active ingredient as in the original product, but the inactive ingredients are slightly different, the brand name will be different and the drug may look different. For more information, see Generic and Branded Drugs. |
Genetic Predisposition
If someone is said to have a genetic predisposition to a particular medical condition, disease or disorder it means that they may inherit the condition from relatives due to the passing on of DNA from one generation to the next. |
Genetic testing
| Genetic testing involves the analysis of human tissue to identify genetic disorders. Further information can be found in the investigations section: Genetic testing for hereditary disorders. |
Genital Discharge
Genital discharges are secretions from the penis or vagina. Many discharges occur normally, but discharges which are smelly or unusually coloured are commonly associated with sexually transmitted infections. |
Genital Herpes
| Genital herpes is a viral infection that is transmitted through sexual contact caused by herpes simplex 1 or 2. Symptoms include burning, tingling and itching followed by blisters which can be painful. These occur around the genital area |
Genital warts
| Genital warts are lesions that are found in the genital area. They can occur in both males and females, and are transmitted via Human Papillomavirus (HPV), mainly through sexual contact with an infected person. |
Genome
| The genome of an organism is its entire genetic information, encoded by DNA (this includes all genes and DNA that does not encode genes). |
Genoptic
Genoptic is a medication used to treat infections of the eye and surrounding structures caused by susceptible bacteria. Common types of infections include conjunctivitis, keratitis and keratoconjunctivitis, corneal ulcers, blepharitis and blepharoconjunctivitis, acute meibomianitis and dacryocystitis. It is also used as prophylaxis after surgery. |
Genoral
| Genoral is a medication used in women who are deficient in oestrogen and suffer from symptoms because of this hormone imbalance. |
Genotype
| Genotype refers to the genetic constitution of a particular individual or population. |
Genoyping
| The characterisation or analysis of an individuals genetic makeup (genotype), which may or may not be expressed (phenotype). |
Genteal
| Genteal is a brand of lubricant eye drops (containing hypromellose) or gel (hypromellose, carbomer 980). |
German measles
| German measles (or Rubella) is a viral illness which may produce a rash, swollen glands, joint pain and muscle pains in infected children or adults. Though most infections are mild, the real danger of rubella infection lies in the risk of Congenital Rubella Syndrome, which may occur if a non-immune pregnant woman becomes infected during the first half of pregnancy. This can have devastating consequences for the baby, which may be born deaf, blind, with heart defects, or mentally retarded. Children and adults can be protected against rubella infection through immunisation. |
Gestation
| Gestation can be used to refer to the period of time between conception and birth or the length of time of the pregnancy. |
Gestational age
| Gestational age is the age of a foetus during pregnancy. |
Gestational Diabetes Mellitus
| Gestational diabetes mellitus is a condition when any degree of glucose (sugar) intolerance is detected with onset or first recognition during pregnancy (gestation). The definition applies if the condition continues beyond pregnancy, and whether or not insulin is required to treat the patient. |
Gestational trophoblastic disease
Gestational trophoblastic disease refers to a range of pregnancy related tumours. The disease is commonly referred to as molar pregnancy. More information Gestational trophoblastic disease |
Gestational trophoblastic neoplasia
| Gestational trophoblastic neoplasia are malignant (i.e. cancerous) forms of gestational trophoblastic disease, also known as gestational trophoblastic tumours. |
Gestational trophoblastic tumours
Gestational trophoblastic tumours are malignant (i.e. cancerous) forms of gestational trophoblastic disease, also known as gestational trophoblastic neoplasia. More information on gestational trophoblastic disease |
Gingival hyperplasia
| An unhealthy condition of the gums where they are red and overgrown. |
Gingivitis
| Gingivitis refers to inflammation of the gingiva (gums), and is seen as painless bleeding during brushing and flossing. Gingivitis is considered the start of gum disease, and can be resolved relatively simply if good dental hygiene is practiced. |
Gland
| A gland is a group of cells that all create the same substance (usually a fluid) either for use in or outside of the body. There are two types of glands: exocrine glands and endocrine glands. |
Glans penis
The glans penis is the enlarged tip (head) of the penis. |
Glanzmann's thrombasthenia
| Glanzmann's thrombasthenia is a rare inheritable disease in which the body's normal blood clotting system has a defect characterised by a problem with platelet-mediated haemostasis, and blood does not clot. This can lead to excessive and unwarranted bleeding. |
Glaucoma
| Glaucoma is a leading cause of blindness. It usually occurs when the fluid pressure inside the eyes slowly rises, damaging the optic nerve. Often there are no symptoms at first, but a comprehensive eye exam can detect it and early treatment can help protect against vision loss. |
Gleason Score
The Gleason score is a method of tumour classification used to classify the cancer into a stage which indicates how severe the cancer is and how likely it is that the treatment will be successful. The Gleason score is used to classify prostate cancer. A numerical score is given to a cancer, from 2 to 10, which is the sum of two Gleason grades (depending on the level of changes the cells in the prostate cancer show). The Gleason score helps determine if a patient is suitable for high intensity focused ultrasound. |
Glial Cell
In addition to neurons, glial cells are the other major type of cells that make up the nervous system. They are also called neuroglia. Glial cells serve to protect and nourish the neurons. Neurons depend on glial cells to grow, nourish themselves, and establish effective synapses.
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Glivec
Glivec is used in the treatment of
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Glomerular Filtration Rate (GFR)
| Glomerular Filtration Rate (GFR) is a measure of the rate at which kidneys filter fluids. The GFR provides an indication of the underlying kidney function, hence is useful for the diagnosis and testing of kidney disease. 2.The glomerular filtration rate (GFR) is the rate at which an ultrafiltrate of plasma is produced by glomeruli per unit of time. The GFR gives the best estimate of the number of functioning nephrons or functional renal mass. |
Glottis
| The glottis forms the entrance to the larynx (voicebox) and is made up of the vocal cords and the space between them. |
Glucocorticoids
| This group of medications refers to a group of steroid hormones, produced by glands located on top of your kidneys, known as adrenal glands. Glucocorticoids can be used in conjunction with bronchodilators, to achieve effective control of lung diseases. |
Glucose
| Glucose, sometimes referred to as dextrose, is a simple sugar available in its free form in fruits and plants. It also occurs in the blood, where it is the main supply of energy for most human cells. In Diabetes Mellitus, levels in the blood are usually high, and may appear in the urine. Glucose in the blood is obtained from the breakdown of food in the digestive system. |
Glucose intolerance
| Glucose intolerance is low levels of insulin, or failure of the body to respond to insulin, despite high levels of glucose. Glucose can not be taken up from the blood and used in the cells, so blood glucose (sugar) levels remain high. |
Glucose-6-phosphate dehydrogenase deficiency
| Glucose-6-phosphate dehydrogenase deficiency is an x-linked recessive genetic disease where the individual has very low levels of the enzyme, glucose-6-phosphate dehydrogenase (G6PD). This enzyme is involved in red blood cell metabolism. |
Glucose-6-phosphate dehydrogenase defiency
| Glucose-6-phosphate dehydrogenase deficiency is an x-linked recessive genetic disease where the individual has very low levels of the enzyme, glucose-6-phosphate dehydrogenase (G6PD). This enzyme is involved in red blood cell metabolism. |
Glutamine
| Glutamine is a non-essential amino acid, which plays numerous roles in the metabolic process. It can however cause intolerance in sensitive individuals. |
Gluteal Fat
Gluteal fat is fat that is stored around the hips and buttocks. |
Gluten
Gluten is a storage protein derived from wheat, barley, rye and a number of other cereals. |
Gluten Free Diet
A gluten free diet is a diet in which all sources of the protein gluten are excluded. Practically, this means excluding wheat, rye, barley and a number of other cereals and their derivatives. For more information, see Gluten Free Diet. |
Gluten-Sensitive Enteropathy
Gluten-sensitive enteropathy is a condition characterised by intolerance to gluten, also known as celiac disease. More on Gluten Free Diet. |
Glycaemic Index
| The Glycaemic Index (GI) is a numerical index assigned to a food. It is obtained by measuring the effect that a carbohydrate containing food has on blood sugar levels, compared to the effect of the same amount of pure sugar, on blood sugar levels. |
Glycaemic Load
| The Glycaemic Load (GL) is defined as a system for ranking the carbohydrate content in food products based on the Glycaemic Index (GI) and serving size. It is determined by multiplying the GI value of the food by the carbohydrate content of the food.This provides us with a more accurate picture of the overall effect that the food product has on blood sugar levels. |
Glycans
| Glycan refers to a polysaccharide, or oligosaccharide. Glycan may also be used to refer to the carbohydrate portion of a glycoconjugate, such as a glycoprotein. |
Glycated haemoglobin
| This level can give us an indication of overall diabetes control and average blood sugar control within the last 2-3 months. The usefulness of the glycated haemoglobin lies in the fact that glucose molecules will permanently attach themselves to haemoglobin molecules and the level of haemoglobin affected can be measured in the blood. |
Glyceryl trinitrate
| Glyceryl trinitrate is a medication used to provide temporary relief from angina. |
Glycogen
| Glycogen is the main energy storage carbohydrate in the body. |
Glycol ether
Glycol ethers are a group of solvents. They are most commonly found as ingredients in paint. |
Glycolipid
| Glycolipids are polar macromolecules that comprise a non-polar fatty acid and a polar carbohydrate molecule. Glycolipids, amongst other roles, form the membranes of cells. |
Glycopeptides
| Antibiotics that fall within this group include: Vancomycin and Teicoplanin. These drugs act by preventing the from making the walls of their cells and also by impairing synthesis of RNA. Both antibiotics are very active against resistant Gram positive organisms. However, they have poorer activity against Gram negative bacteria. |
Glycoprotein
| A glycoprotein is a protein joined to a carbohydrate. |
Goitre thyroid enlargement
| A goitre is an enlargement of the thyroid gland. |
Gomphosis (dentoalveolar syndesmosis)
| Gomphosis (dentoalveolar syndesmosis) consists of a bone with processes (tooth) that slot into an articulation socket, producing a joint which is immobile. |
Gonadotroph
| A gonadotroph is a specific cell (basophilic cell) which secretes follicle-stimulating hormone or luteinising hormone from the anterior pituitary. |
Gonadotrophin Releasing Hormone (GnRH)
| Gonadotrophin Releasing Hormone (GnRH) is a hormone that is responsible for the stimulation of specific cells called gonadotrophs in the pituitary gland. This stimulation results in the production of two important hormones called LH (luteinising hormone) and FSH (follicular stimulating hormone) from the pituitary. GnRH is of great importance in the menstrual cycle. One of the most important features of GnRH release is the fact that its release occurs in a pulsatile fashion. At the start of puberty there is a marked increase in the frequency and amplitude of GnRH release. |
Gonadotrophins
Gonadotrophins are hormones produced by the pituitary gland that act on the gonads (the sexual organs) to effect various endocrine functions. |
Gonioscopy
| Gonioscopy refers to the process used to view the iridocorneal angle of the eye, which is the anatomical angle formed between the cornea and the iris. |
Gonorrhoea (GC)
| Gonorrhoea is a sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae. It can be passed on by vaginal, oral or anal intercourse. |
Gordon Diagnostic System
The Gordon Diagnostic System is a series of game-like tests that assess both attention and impulsivity. The system includes a "vigilance task", which shows the child a series of digits, one at a time. The child must identify every time a particular sequence of numbers appear (e.g. a 1 followed by a 9). This test is performed once visually, and once with the child listening to the numbers. There is also a test to check for impulsivity. The Gordon Diagnostic System has been validated for children between the ages of 4 and 16. |
GPR - Good partial remission
| A reduction in more than 75% of the tumour mass. |
Graafian follicle
| The graafian follicle forms in the adult ovary. There is proliferation of the granulosa cells with the formation of a fluid filled cavity called the antrum. The granulosa cells nearest the zona pellucida form the corona radiata, which is released as a part of the oocyte during ovulation. The Graafian follicle is the chosen follicle, and the remaining follicles undergo atresia. |
Graft-versus-host disease (GVHD)
Graft-versus-host disease (GVHD) is a common complication of allogeneic bone marrow transplantation in which the transplanted marrow recognise the recipient as "foreign" and mount an immunologic attack. |
Granulocyte
| A granulocyte is a type of white blood cell and part of the immune system that when looked at under a microscope seems to have lots of little granules of substances inside them. The type of granules determine what type of cell it is. They are divided into three types: neutrophils, basophils and eosinophils. |
Granulocyte-CSF (G-CSF)
| Granulocyte-CSF (G-CSF) is a protein which interacts with receptors on the surface of primitive bone marrow cells. Granulocyte-CSF (G-CSF) stimulate them to produce adult cells. |
Granulocyte-macrophage colony stimulating factor (GM-CSF)
| Granulocyte-macrophage colony stimulating factor (GM-CSF) is a protein which interacts with receptors on the surface of the primitive bone marrow cells. Granulocyte-macrophage colony stimulating factor stimulates them to produce adult cells. |
Granulosa cells
Granulosa cells are oestrogen-secreting cells that help nourish the oocyte during its development by releasing estradiol. After ovulation the granulosa cells become luteal cells of the corpus luteum that produce progesterone. The release of this hormone from the corpus luteum helps maintain pregnancy in women and also produces a thick cervical mucus which inhibits sperm into the uterus. |
Graves' Ophthalmopathy (Thyroid Eye Disease)
| Graves' ophthalmopathy is an eye disorder found in individuals with Graves' disease. It is characterised by inflammation of the eye and fat in the eye socket. In severe cases inflammation can compress the optic nerve, leading to blindness. The condition is also known as thyroid eye disease. |
Grey matter
| Grey matter makes up part of the central nervous system and is mainly made up of cell bodies and dendrites. It is called grey matter because it has a grey appearance in fresh material. |
Growth factors
Growth factors are those agents that stimulate epithelial proliferation. It can refer to medication or even naturally occurring substances in the body (usually proteins or steroids). They are important in maintaining cellular processes. |
Growth Hormone
Growth hormone is a hormone produced by the pituitary gland. It plays a key role in the body's growth and development. An excess of growth hormone leads to the condition known as acromegaly, or gigantism. Artificial growth hormone may be administered as a drug in order to treat certain medical conditions (such as obesity). |
Gynacoid
| The shape of a female's body is referred to as gynacoid, or "pear-shaped". This shape describes the distribution of body fat on the hips and thighs as a pose to males who carry weight in the abdominal region. Male's bodies are described as android or "apple-shaped". Females on average naturally have a higher total and percentage of body fat than men. |
Gynaecologist
| A gynaecologist is a medical doctor who specialises in treating diseases particular to women. |
Gynaecomastia
| The development of breast tissue in males. |
Gyrus
| A gyrus (pl. gyri) is defined as an elevation or "hill" on the surface of the brain. A gyrus is generally surrounded by one or more sulci. |





