Timentin

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Generic Name: Potassium clavulanate; Ticarcillin sodium
Product Name: Timentin

Indication of Timentin
Action of Timentin
Dose advice of Timentin
Schedule of Timentin
Common side effects of Timentin
Uncommon side effects of Timentin

Indication of Timentin:

Used for the treatment of serious infections caused by beta lactamase producing organisms susceptible to Timentin Including: Septicaemia (and bacteremia), Lower respiratory tract infections, Bone and joint infections, Skin and connective tissue infections, Urinary tract infections, Gynaecological infections. Timentin may be used perioperatively in patients undergoing abdominal hysterectomy or elective colorectal surgery when a significant risk of postoperative infection is present.

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Action of Timentin:

Ticarcillin kills bacteria while they are multiplying. The addition of clavulanic acid offers beta lactamase inhibition to extend the antibacterial spectrum Susceptible organisms include: Gram Negative bacteria: P.aeruginosa, E.coli, P.mirabilis, P.vulgaris, Providencia rettgeri, Morganella morganii, Enterobacter sp, H.influenzae, N.meningitidis, Salmonella sp, K.pneumoniae, and some strains of Mima, Herellea, Citrobacter and Serratia. Gram Positive bacteria: S.aureus, S.epidermidis, S.pneumoniae, S.faecalis, S.pyogenes Anaerobic bacteria: Bacteroides sp, Clostridium sp, Eubacterium sp, Fusobacterium sp, Peptococcus sp, Peptrostreptococcus sp, Veillonella sp. Peak serum concentrations (of both ticarcillin and clavulanic acid) are achieved immediately after completion of the infusion. Mean serum half lives for ticarcillin and clavulanic acid in healthy volunteers are 68 and 64 minutes respectively. A majority of the ticarcillin and close to half of the clavulanic acid is excreted unchanged in the urine during the first six hours after a single dose. Neither component is especially protein bound. Timentin may be removed during dialysis.

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Dose advice of Timentin:

Patients > 60 kg: 3.1 g intravenously, every four to six hours, except in urinary tract infections where it is given every 8 hours. Patients < 60 kg: 200-300 mg/kg/day intravenously, given in divided doses every four to six hours. Patients with renal insufficiency. Loading dose 3.1 g intravenously. Maintenance dose is adjusted according to creatinine clearance. Creatinine clearance > 60 mL/min: 3.1 g intravenously, every 4 hours. Creatinine clearance 30-60 mL/min: 2 g intravenously, every 4 hours. Creatinine clearance 10-30 mL/min: 2 g intravenously, every 8 hours. Creatinine clearance < 10 mL/min: 2 g intravenously, every 12 hours. Creatinine clearance <10 mL/min with hepatic impairement: 2 g intravenously, every 24 hours. Peritoneal dialysis: 3.1 g intravenously, every 12 hours. Haemodialysis: 2 g intravenously, every 12 hours Prophylaxis: Caesarean section: Three 3.1 g intravenous doses. One dose as the umbilical cord is clamped, and two further doses every four hours after the first dose. Abdominal hysterectomy: Three 3.1 g intravenous doses. One dose, half to one hour prior to the initial incision, followed by two further doses every four hours after the first dose. Elective Colorectal Surgery: Three 3.1 g intravenous doses. One dose half to one hour prior to the initial incision, followed by two additional doses every eight hours after the first dose. An alternate regimen is to give two 3.1 g doses, one 15 minutes prior to induction of anaesthesia, followed two hours later by a second dose

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Schedule of Timentin:

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Common side effects of Timentin:

Local reaction at injection site: pain, redness, burning, swelling, thromboplebitis. Skin rash, pruritis, urticaria, arthralgia, myalgia Headache, giddiness Disturbances of taste and smell, nausea, vomiting, diarrhoea, flatulence, epigastric pain.

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Uncommon side effects of Timentin:

Erythema multiforme, Stevens Johnson syndrome. Thrombocytopenia, increased bleeding and prothrombin times, eosinophilia, immune haemolytic anaemia Abnormalities of renal and hepatic function tests.

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