Fungilin

Generic Name: Amphotericin
Product Name: Fungilin

• Indication of Fungilin
• Action of Fungilin
• Dose advice of Fungilin
• Schedule of Fungilin
• Common side effects of Fungilin
• Uncommon side effects of Fungilin

Indication of Fungilin:

Used in the treatment of invasive fungal infections caused by organisms susceptible to amphotericin, in adults and children > 12 years old.

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Action of Fungilin:

Microbiology. Amphocin is a stable complex of Amphotericin B and sodium cholesterol sulfate, and is slightly less effective than conventional Amphotericin B at equivalent doses, though at higher tolerated doses it is equivalent to of more effective than Amphotericin B. Amphotericin is a macrocyclic antibiotic with fungicidal activity against a variety of fungal species. Pharmacokinetics. Mean terminal half lives for doses < 2.0 mg/kg and > 2.0 mg/kg are approximately 22.1 and 27.2 hours respectively.

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Dose advice of Fungilin:

Adults. 3-4 mg/kg, once daily. (Doses as high as 6 mg/kg have been used). Children. Experience is limited, though some patients have been treated with daily doses per kilogram similar to those used in adults with no unusual adverse effects. Elderly patients. Experience is limited, though available data does not indicate that dose reductions or precautions are required. Use in pregnancy. Amphocil use should be avoided during pregnancy unless the expected benefit outweighs the risk. Use in lactation. Amphocil use is not recommended in breastfeeding women. Use in children. Specific dose recommendations and precautions have not been sufficiently studied in the paediatric populations.

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Schedule of Fungilin:

S4

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Common side effects of Fungilin:

Fever, chills. Nausea, vomiting, diarrhoea, abdominal pain. Headache, backache. Rash Abnormalities of kidney (e.g. hypokalemia, increased creatinine, increased urea) and liver (e.g. bilirubinaemia, increased alkaline phosphatase) biochemistry.

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Uncommon side effects of Fungilin:

As above.

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Diseases treated by Fungilin:

• Oral Candidiasis (Oropharyngeal Candidiasis, Oral Thrush, OPC, OC)  (Oral Thrush (Monoliasis, Oral Candidiasis, OC))

For further information talk to your doctor.

Article Dates:

Created: 22/7/2003