Virtual Medical Centre

Drugs

Natulan

Generic Name: Procarbazine hydrochloride
Product Name: Natulan

• Indication of Natulan
• Action of Natulan
• Dose Advice of Natulan
• Schedule of Natulan
• Common side effects of Natulan
• Uncommon side effects of Natulan

Indication of Natulan:

Natulan is used in the treatment of Hodgkin's lymphoma and other malignant lymphomas including:
- lymphosarcoma
- reticulosarcoma
- Brill-Symmers disease
Because it works differently to other anticancer agents, Natulan may be useful in the treatment of cancers that have not responded to other treatments.

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Action of Natulan:

Procarbazine is a cytostatic agent, meaning it strands cells midway through cell division, but it does not actively kill them. It interferes with cells at a number of sites to prevent DNA and protein synthesis and mitosis.

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Dose Advice of Natulan:

Natulan is for oral administration.
- begin with 50mg dose
- increase gradually (50mg/day) to 250-300mg/day
- maintain this dose until greatest possible disease remission has occurred
- treatment should be suspended if platelets drop below 80,000/mm3 or white blood cells drop below 3,000/mm3, and not recommenced until these levels have normalised

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