Pariet

Drugs

Generic Name: Rabeprazole sodium
Product Name: Pariet

Indication of Pariet
Action of Pariet
Dose Advice of Pariet
Schedule of Pariet
Common side effects of Pariet
Uncommon side effects of Pariet
Reference

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Indication of Pariet:

Pariet is used for the treatment of:

Stomach ulcers
Ulcers in the duodenum (the area of the small intestine that lies just after the stomach)
The symptoms of gastroesophageal reflux disease

In combination with two antibiotic agents, Pariet is used for the eradication of Helicobacter pylori. Helicobacter pylori is a bacteria that is strongly linked to stomach ulcerations and chronic gastritis.

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Action of Pariet:

Pariet relieves the symptoms of reflux and ulcers by slowing down the secretion of acid by the cells that line the stomach. It does this by inhibiting a single type of enzyme (a protein that allows other chemical reactions to occur faster) called a 'proton pump' that is needed to produce acid. So, by inhibiting this enzyme, the final stage in acid production is stopped.

The acid suppression effect of Pariet occurs very quickly (within 2-4 hours) and lasts up to 23 hours after the first dose. Normal acid production can be decreased by 69%. Also at 23 hours, the amount of acid produced when eating food (which is when a lot of acid is created) is reduced by 82%.

The symptoms of many of the conditions treated by Pariet are very similar. Your doctor can sometimes recommend a medical procedure called an endoscopy, where a flexible fibre-optic tube is passed down the throat into the stomach, allowing the gastroenterology doctor to see the exact cause of the symptoms. People are put into a light sleep for the few minutes it takes to do the test, and most people have no recollection of it afterwards.

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Dose Advice of Pariet:

The dosage of Pariet will depend on what condition is being treated. The usual doses are as follows:

Condition	Dose
Active reflux	20mg once daily for 4-8 weeks. If the symptoms persist, then 20mg twice daily (total 40mg per day) can be used for a further 4 weeks.
Maintenance of reflux treatment	Dosage should be lowered to the minimum amount, usually between 10-20mg daily.
Symptomatic treatment of reflux	Dosage usually begins at 10mg per day, increasing to 20mg per day if there is no response. Once symptoms have resolved, subsequent symptom control can be achieved using a regimen of one 10 mg tablet taken once daily when needed.
Treatment of duodenal ulcers	20mg once a day for 4-8 weeks.
Treatment of stomach ulcers	20mg once a day for 6-12 weeks.
Eradication of Helicobacter pylori bacteria	Usually 20mg of Pariet twice a day, in combination with two antibiotics.