Virtual Medical Centre

Drugs

Mestinon

Generic Name: Pyridostigmine bromide
Product Name: Mestinon

• Indication of Mestinon
• Action of Mestinon
• Dose Advice of Mestinon
• Schedule of Mestinon
• Common side effects of Mestinon
• Uncommon side effects of Mestinon

Indication of Mestinon:

- This drug is used for the management of myasthenia gravis

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Action of Mestinon:

- Mestinon competitively inhibits a cholinesterase enzyme (used for breaking down the neurotransmitter acetylcholine) that normally hydrolyses acetylcholine at synapses and neuronal junctions
- The result is a cholinergic effect which leads to increased skeletal tone and increased intestinal movement as well as other effects including pupil contraction, uterine and bronchial muscle activity, and increased secretions
- Mestinon also acts directly on skeletal muscle in a way similar to acetylcholine to increase muscle tone

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Dose Advice of Mestinon:

- 1-3 60mg Mestinon tablets, 2-4 times daily; more for severe cases
- Alternatively, 1-3 Mestinon Timespan (180mg) tablets, 1-2 daily with the interval being at least 6 hours

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