Small Intestine Cancer (Lymphoma of the Small Intestine)
- What is Small Intestine Cancer?
- Statistics on Small Intestine Cancer
- Risk Factors for Small Intestine Cancer
- Progression of Small Intestine Cancer
- How is Small Intestine Cancer Diagnosed?
- Prognosis of Small Intestine Cancer
- How is Small Intestine Cancer Treated?
- Small Intestine Cancer References
- Drugs/Products Associated with Small Intestine Cancer
What is Small Intestine Cancer?
Lymphomas of the small bowel may be primary (i.e. arising from the small bowel lymph tissue) or secondary to a systemic lymphoma. The small bowel is composed of the duodenum, jejenum, and ileum. It is the part of the Gastro-Intestinal tract extending from the pyloric sphincter of the stomach to the ileo-caecal valve separating the ileum from the colon (large bowel).
Statistics on Small Intestine Cancer
Primary lymphomas of the small intestine are rare - comprising 1-3% of gastro-intestinal malignancies, however, they are the second most common small bowel tumour after adenocarcinomas.
Risk Factors for Small Intestine Cancer
Predisposing factors may include:
Progression of Small Intestine Cancer
The boewl cancer may grow locally into the lumen of the bowel causing obstruction, or sometimes causing perforation. Sometimes the bowel cancer spread along the mucosal surface to involve a wide area - causing malabsorption. Lymph node spread to mesenteric nodes, and subsequently other lymph node groups and systemic spread may occur similar to other lymphomas.
How is Small Intestine Cancer Diagnosed?
Prognosis of Small Intestine Cancer
Bowel cancer prognosis depends on the stage at which the disease is diagnosed and treated. With tumours treated adequately with a curative intent the 5 year survival is as much as 80%. Even with more advanced disease there may be favourable prognosis if the tumour responds to chemotherapy.
How is Small Intestine Cancer Treated?
Small Intestine Cancer References
- Cotran RS, Kumar V, Collins T. Robbins Pathological Basis of Disease Sixth Ed. WB Saunders Company 1999.
- Kumar P, Clark M. Clinical Medicine. Fourth Ed. WB Saunders, 1998.
- Tjandra, JJ. Small bowel tumours. In: Tjandra JJ., Clunie GJA., Thomas RJS. Textbook of surgery, 2nd Ed. Blackwell Science Asia 2001.
Regimens Used in the Treatment of This Disease:
- ICE (Ifosphamide + Carboplatin + Etoposide)
- IMVP16 (Ifosphamide + Methotrexate + Etoposide)
- IVE (Ifosfamide + Vincristine + Etoposide)
- R-IME (Rituximab + Ifosphamide + Mitrozantrone + Etoposide)
Drugs/Products Used in the Treatment of This Disease:
- Adriamycin Solution (Doxorubicin hydrochloride)
- Doxorubicin Hydrochloride Injection (DBL) (Doxorubicin hydrochloride)
- Doxorubicin Hydrochloride Injection USP (Doxorubicin hydrochloride)
Modified: 7/2/2008 Created: 8/2/2004
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