Pulmonary Heart Disease - Cor Pulmonale
- What is Pulmonary Heart Disease - Cor Pulmonale?
- Statistics on Pulmonary Heart Disease - Cor Pulmonale
- Risk Factors for Pulmonary Heart Disease - Cor Pulmonale
- Progression of Pulmonary Heart Disease - Cor Pulmonale
- How is Pulmonary Heart Disease - Cor Pulmonale Diagnosed?
- Prognosis of Pulmonary Heart Disease - Cor Pulmonale
- How is Pulmonary Heart Disease - Cor Pulmonale Treated?
- Pulmonary Heart Disease - Cor Pulmonale References
- Drugs/Products Associated with Pulmonary Heart Disease - Cor Pulmonale
What is Pulmonary Heart Disease - Cor Pulmonale?
Pulmonary Heart Disease or Cor Pulmonale is an alteration in the structure and function of the right ventrical caused by a primary disorder of the respiratory system.
Statistics on Pulmonary Heart Disease - Cor Pulmonale
Primary pulmonary hypertension is a rare disease. It is found in 0.1-0.2% of all patients at autopsy, but many are asymptomatic (showing no symptoms) until late in the process.
Risk Factors for Pulmonary Heart Disease - Cor Pulmonale
Most cases of pulmonary hypertension are secondary to lung disease. Almost any chronic lung disease can cause it.However in clinical practice, by far and away the predominant causes are:1) Pulmonary embolism in the acute setting2) COPD (eg emphysema, chronic bronchitis) in the chronic setting.Primary pulmonary hypertension, as the name suggests, has no known cause.
Progression of Pulmonary Heart Disease - Cor Pulmonale
This depends on the aetiology (origins) of the underlying cause of the pulmonary hypertension. In cases of pulmonary embolism, one or many embolic clots (usually from the deep veins of the leg) occlude a part of the pulmonary arterial vasculature. In time, this results in increased pulmonary pressure, decreased cardiac output and a sydrome of right heart failure, usually with no cardiac compensation. In the chronic setting (as in COPD) the pulmonary hypertension is due to changes to the lung tissues themselves. This is often associated with compensatory right heart changes, and eventually right heart failure.
How is Pulmonary Heart Disease - Cor Pulmonale Diagnosed?
1) Chest x-ray: may show evidence of right ventricular hypertrophy or atrial dilatation in the chronic setting. Prominent pulmonary arteries may be seen. May also show pulmonary effusions or infarctions secondary to embolism. 2) ECG: can demonstrate right ventricular hypertrophy and ischaemia. Tall tented p-pulmonale may also be seen. 3) Echocardiography may show dilatation and also allows indirect measurement of pulmonary artery pressures.
Prognosis of Pulmonary Heart Disease - Cor Pulmonale
The prognosis of pulmonary heart disease depends on the underlying causes. However, disease serious enough to cause significant right heart failure (usually massive pulmonary embolism or end stage COPD) are associated with poor prognoses. Mild to moderate pulmonary emboli have the best outlook. Primary pulmonary hypertension has a poor prognosis with a porgressive course - heart and lung transplantation is an option in younger patients.
How is Pulmonary Heart Disease - Cor Pulmonale Treated?
The treatment of pulmonary heart disease largely rests with treating the underlying cause and supportive measures. Oxygen therapy may slow progression.Right heart failure secondary to pulmonary pathology should be treated similarly to congestive heart failure. Vasodilators such as the calcium channel blockers may be particularly useful in reducing the pressure of the pulmonary circulation.
Pulmonary Heart Disease - Cor Pulmonale References
 Hurst's The Heart 8th Edition, McGRAW-HILL 1994. Kumar and Clark Clinical Medicine 4th Edition, W.B SAUNDERS 1998.
Drugs/Products Used in the Treatment of This Disease:
- Dilzem (Diltiazem hydrochloride)
- Felodur ER (Felodipine)
- Glyceryl Trinitrate for Injection (DBL) (Glyceryl trinitrate)
- Imdur Durules (Isosorbide mononitrate)
- Nifecard (Nifedipine)
- Norvasc (Amlodipine besylate)
|Modified: 11/2/2008||Created: 26/5/2003|
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