Polyarteritis Nodosa (PAN)
- What is Polyarteritis Nodosa?
- Statistics on Polyarteritis Nodosa
- Risk Factors for Polyarteritis Nodosa
- Progression of Polyarteritis Nodosa
- How is Polyarteritis Nodosa Diagnosed?
- Prognosis of Polyarteritis Nodosa
- How is Polyarteritis Nodosa Treated?
- Polyarteritis Nodosa References
- Drugs/Products Associated with Polyarteritis Nodosa
What is Polyarteritis Nodosa?
Polyarteritis nodosa (PAN) is a multisystem disease that affects small to medium sized blood vessels. Typically it affects the renal, intestinal, muscular and cardiac circulations.
Statistics on Polyarteritis Nodosa
Polyarteritis nodosa is rare. Incidence ranges from 2-6 per 100 000 people in most populations, but may be higher in populations where hepatitis B is common.
Risk Factors for Polyarteritis Nodosa
PAN can occur at any age but is most common around 40-60 years. Men are twice as likely to be affected as women. 30% of patients with PAN also have an active hepatitis B infection. In the majority of patients, the cause of PAN is presently unknown.
Progression of Polyarteritis Nodosa
PAN may affect any organ system in the body.
How is Polyarteritis Nodosa Diagnosed?
A number of tests may help make the diagnosis of PAN:
Prognosis of Polyarteritis Nodosa
Untreated, PAN has a high mortality rate. 5 year survival following treatment with corticosteroids and cyclophosmide is currently better than 80%.
How is Polyarteritis Nodosa Treated?
Treatment of PAN has improved greatly over the past few decades. Before the availability of effective treatment, PAN was fatal in most patients within months to years, usually as a result of kidney or heart complications. Today PAN is treated with a combination of steroids and chemotherapy agents. This brings about cure or remission in 90% of patients.
Polyarteritis Nodosa References
 Chung S. Polyarteritis Nodosa. eMedicine 2004. [available online @ http://www.emedicine.com/neuro/topic314.htm] Cotran, Kumar, Collins. Robbins Pathological Basis of Disease, 6th ed. WB Saunders, United States of America (1999). Hankey G., Wardlaw J. Clinical Neurology. Demos Medical Publishing, United Kingdom, 2002.  Savage, Harper, Cockwell, et al. ABC of arterial and vascular disease. BMJ 2000;320:1325-1328. The John Hopkins Vasculitis Center. [available online @ http://vasculitis.med.jhu.edu/typesof/polyarteritis.html] Watts, Scott. ABC of Rheumatology: Rashes and Vasculitis. BMJ 1995;310:1128-1132.
Drugs/Products Used in the Treatment of This Disease:
- Cycloblastin (Cyclophosphamide)
- Methylprednisolone Sodium Succinate for Injection USP (DBL) (Methylprednisolone sodium succinate)
|Modified: 11/2/2008||Created: 22/11/2004|
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