Peripheral T cell lymphoma
- What is Peripheral T cell lymphoma?
- Statistics on Peripheral T cell lymphoma
- Risk Factors for Peripheral T cell lymphoma
- Progression of Peripheral T cell lymphoma
- How is Peripheral T cell lymphoma Diagnosed?
- Prognosis of Peripheral T cell lymphoma
- How is Peripheral T cell lymphoma Treated?
- Peripheral T cell lymphoma References
What is Peripheral T cell lymphoma?
Peripheral T cell lymphoma means cancer of the lymphatic system. The lymphatic system is important to our immune system where it helps to combat infection. The lymphatic system consists of several organs, e.g. lymph nodes, spleen, thymus and bone marrow, where all these are connected by tiny vessels. Lymphatic fluid is the medium that circulates in these tiny vessels. Like blood, it has cells in them. These cells can be divided into 2 types: T cells and B cells.Lymphoma is divided into 2 broad groups: Hodgkin's lymphoma and non-Hodgkin's lymphoma. Peripheral T cell lymphoma is a non-Hodgkin's lymphoma. As the name suggests, it primary affects the T cells. Peripheral T cell lymphoma has many subtypes as well, just to confuse the matter.
Statistics on Peripheral T cell lymphoma
Lymphoma is on the increase in the world over the years. The following figures is according to the Australian statistics:
Risk Factors for Peripheral T cell lymphoma
Age: More common in adults than childrenGender: Men are affected more than women but only slightly
Progression of Peripheral T cell lymphoma
Clinically and historically, non-Hodgkin's lymphoma can be subdivided into 2 groups: indolent (low grade) and aggressive (high grade) lymphomas. Peripheral T cell lymphoma is under the aggressive group - which means it has worse prognosis but may respond to treatment modalities better than indolent group of lymphomas.The course of the disease is dependent on the clinical stage when the disease is diagnosed. The later the stage, the more advanced the disease is, hence worse outcome with the disease.The staging for non-Hodgkin lymphoma (which is applicable for peripheral T cell lymphoma) can be summarised as below:Stage I - involvement of a single lymph node region or organ or site other than lymph nodesStage II - 2 or more lymph node regions involved on the same side of diaphragmStage III - 2 or more lymph node regions involved on both sides of diaphragmStage IV - one or more organs (eg bone marrow) involvedEach stage is subclassified into A and B (eg IIA), where B means presence of B symptoms (see below) while A means abscence of the following symptoms:
How is Peripheral T cell lymphoma Diagnosed?
The usual basic tests will be done, including those to look at the blood and other blood components. Other general tests will determine the function of the liver.
Prognosis of Peripheral T cell lymphoma
Generally the prognosis is worse than of B-cell lymphomas. Peripheral T-cell lymphoma is considered an aggressive non-Hodgkin's lymphoma.The prognosis is dependent on the clinical stage when the disease is diagnosed. The later the stage, the worse the prognosis.Some criteria are associated with worse prognosis:
How is Peripheral T cell lymphoma Treated?
Peripheral T cell lymphoma is an aggressive lymphoma - it usually requires treatment options. The following treatment methodscan either be used alone or in combination depending on the state of the disease.The following treatment methods are typically used:
Peripheral T cell lymphoma References
 Cancer in Australia 2001 [online]. 2004 [Cited 2005 September 10th]. Available from: URL: http://www.aihw.gov.au/publications/can/ca01/ca01-c03.pdf Clinical and pathologic features of mature peripheral T and NK cell lymphomas. 2005 [Cited 2005 September 10th]. Available from: URL: http://uptodateonline.com/application/topic.asp?file=lymphoma/12843 Lymphoma - An Overview [online]. 2004 [Cited 2005 September 10th]. Available from: URL: http://www.nccs.com.sg/epub/CU/vol2_04/lymphoma.htm
|Modified: 7/2/2008||Created: 11/9/2005|
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