Diverticular Disease (Diverticulosis; Diverticulitis)
- What is Diverticular Disease?
- Statistics on Diverticular Disease
- Risk Factors for Diverticular Disease
- Progression of Diverticular Disease
- How is Diverticular Disease Diagnosed?
- Prognosis of Diverticular Disease
- How is Diverticular Disease Treated?
- Diverticular Disease References
- Drugs/Products Associated with Diverticular Disease
What is Diverticular Disease?
Diverticular disease is a disease of the colon. Diverticula are little outpouchings of the wall of the colon. Although they can be found in smaller numbers in the stomach or small intestine, "diverticular disease" refers to when they are found in the large bowel (usually sigmoid colon). "Diverticulitis" refers to when there is inflammation of the colon at the site of the diverticula - usually as a result of one of the diverticula becoming blocked.
The image below is indicative of diverticulitis. The arrow indicates an area within the sigmoid colon that is suffering from diverticulitis.
Statistics on Diverticular Disease
The condition is common in the West. It is rare before the age of 35, but the incidence increases with age (25% in those over 40 years old in Western society) although it is mostly asymptomatic. It is uncommon in countries where a high fibre diet is consumed.
Risk Factors for Diverticular Disease
Since this condition is mainly seen in areas of low fibre intake - this is considered to be the main risk factor. Less fibre results in harder, more compact stools which require more pressure within the colon to propel them along. These high pressures lead to diverticular formation.
Progression of Diverticular Disease
Although this condition is common, most patients are asymptomatic. Out of the symptomatic patients (who present with diverticulitis or bleeding) - only 30% will develop troublesome enough complications and have a severe enough disease to require an operation. The disease will usually lead to isolated attacks of diverticulitis or haemorrhage (blood loss per rectum) which will usually subside with conservative management, but can potentially be complicated by abscess formation, perforation, or stricture. Complications such as these may be fatal if untreated.
In uncomplicated cases (where there is diverticulitis but no perforation or abscess) early intervention with appropriate antibiotics may alow for better treatment.
How is Diverticular Disease Diagnosed?
- A high white cell count (on full blood examination) will suggest inflammation.
- There may be electrolyte abnormalities in keeping with dehydration.
- An erect (standing) chest x-ray should also be performed to evaluate any air under the diaphragm suggestive of perforation.
Prognosis of Diverticular Disease
Patients (which is only a small proportion of the ones with diverticular disease) which have presented with an attack of diverticulitis can have very variable prognosis. Uncomplicated diverticulitis usually settle on its own with conservative management. However, if the disease is complicated by an abscess, perforation, or severe haemorrhage the mortality can be high. Furthermore, patients who have had more than 2 episodes of uncomplicated diverticulitis are likely to develop further episodes. These patients usually require a surgery (the involved segment of bowel is resected) either at the time of hospital admission (in complicated cases), or later to prevent further episodes.
How is Diverticular Disease Treated?
Patients with diverticular disease should be counselled on the benefits of a high fibre diet. Bulking agents and laxatives could also be added until stools are soft and defaecation is painless.
Patients with acute diverticulitis are admitted to hospital for bed rest, nil by mouth (with iv fluids), analgesics, and IV antibiotics (e.g. cefuroxime and metronidazole). Patients presenting with PR bleeding are resuscitated and given blood transfusion.
Complicated disease (perforation, abscess, multiple attacks, uncontrollable bleeding) usually requires surgery to remove the diseased segment of colon. There are various surgical techniques available depending on the site of the disease, and a temporary stoma is usually needed (a "stoma bag"), although this is reversed after around 6 weeks.
Diverticular Disease References
- Braunwald, Fauci, Kasper, Hauser, Longo, Jameson. Harrison's Principles of Internal Medicine. 15th Edition. McGraw-Hill. 2001.
- Cotran, Kumar, Collins 6th edition. Robbins Pathologic Basis of Disease. WB Saunders Company. 1999.
- Haslet C, Chiliers ER, Boon NA, Colledge NR. Principles and Practice of Medicine. Churchill Livingstone 2002.
- Hurst JW (Editor-in-chief). Medicine for the practicing physician. 4th edition Appleton and Lange 1996.
- Kumar P, Clark M. CLINICAL MEDICINE. WB Saunders 2002.
- Longmore M, Wilkinson I, Torok E. OXFORD HANDBOOK OF CLINICAL MEDICINE. Oxford Universtiy Press. 2001
- McLatchie G and LEaper DJ (editors). Oxford Handbook of Clinical Surgery 2nd Edition. Oxford University Press 2002.
- MEDLINE Plus
- Raftery AT Churchill's pocketbook of Surgery. Churchill Livingsone 2001.
- Tjandra, JJ, Clunie GJ, Thomas, RJS,; Textbook of Surgery, 2nd Ed, Blackwell Science, Asia. 2001.
Symptoms of This Disease:
Drugs/Products Used in the Treatment of This Disease:
- Actilax (Lactulose)
- Benefiber (Laxatives)
- Coloxyl with Senna (Docusate sodium; Sennosides A and B)
- Durolax (Bisacodyl)
- Fybogel (Ispaghula)
- Glycerin Suppositories (Glycerol)
- Normafibe (Sterculia)
- Senokot (Sennosides A and B)
|Modified: 10/11/2009||Created: 26/9/2003|
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