- What is Cushing's syndrome?
- Statistics on Cushing's syndrome
- Risk Factors for Cushing's syndrome
- Progression of Cushing's syndrome
- How is Cushing's syndrome Diagnosed?
- Prognosis of Cushing's syndrome
- How is Cushing's syndrome Treated?
- Cushing's syndrome References
What is Cushing's syndrome?
Cushing's syndrome refers to the syndrome associated with excessive levels of a type of hormones - glucocorticoids. Glucocorticoids (mainly cortisol) are secreted naturally by the adrenal cortex in response to stimulation from the pituitary gland (ACTH hormone), which in turn responds to CRH secretion from the hypothalamus.Because glucocorticoids like cortisol have such widespread effects on metabolism and the immune system, the symptoms and signs of Cushing's syndrome are wideranging.Cushing's syndrome can result from excess secretion of cortisol from the adrenal gland, or in response to excessive secretion of ACTH from the pituitary gland (e.g. a tumour) or due to adrenocorticotrophic hormone (ACTH) secretion from an ectopic (unusual) site e.g. a lung tumour. Cushing's disease is a term used to describe Cushing's syndrome from excessive production of ACTH by a pituitary tumour. Cushing's syndrome can also result from the administration of corticosteroids for medical reasons (e.g severe asthma, as an immunosuppresant - e.g. kidney transplant recipients).
Statistics on Cushing's syndrome
The prevalence is approximately 40 per million and the incidence is 1-2 cases per million population. As far as the different subgroups:
Risk Factors for Cushing's syndrome
Progression of Cushing's syndrome
The onset and progression can be gradual of fulminant. Morbidity and mortality result from diabetes and hypertension associated vascular complications, osteoporosis with compression fractures, infection, thromboembolic phenomena and emotional disturbances.
How is Cushing's syndrome Diagnosed?
Prognosis of Cushing's syndrome
Mortality from untreated Cushing's syndrome is almost 50% at 5 years. Mortality and morbididy are reduced with effective treatment.
How is Cushing's syndrome Treated?
Cushing's syndrome References
 Longmore M, Wilkinson I, Torok E. OXFORD HANDBOOK OF CLINICAL MEDICINE. Oxford Universtiy Press. 2001 Kumar P, Clark M. CLINICAL MEDICINE. WB Saunders 2002 Pg 427-430. Hurst JW (Editor-in-chief). Medicine for the practicing physician. 4th edition Appleton and Lange 1996. Braunwald, Fauci, Kasper, Hauser, Longo, Jameson. Harrison's Principles of Internal Medicine. 15th Edition. McGraw-Hill. 2001 Cotran, Kumar, Collins 6th edition. Robbins Pathologic Basis of Disease. WB Saunders Company. 1999.
Treatments Used in This Disease:
|Modified: 6/2/2008||Created: 7/9/2003|
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