Research & Trials
Australasian Resuscitation In Sepsis Evaluation Randomised Controlled Trial (ARISE)
The ARISE RCT is a multi-centre, randomised, controlled trial of EGDT compared to standard care in patients with severe sepsis presenting to the ED. The study will be conducted in multiple sites ... › More
Safety and Efficacy Study of MPC-4326 for Treatment of Patients With HIV-1 Infection
To evaluate the antiretroviral activity and safety of 200 mg BID and 300 mg BID doses of MPC-4326 administered as monotherapy for 14 days to HIV-1 positive patients. Patients with an initial ... › More
Repeat Dose Safety Study for Compound to Treat Anaemia
The purpose of this study is to characterise the safety and tolerability of repeat doses of compound 1278863A in healthy subjects. › More
A Study Evaluating Safety and Immunogenicity of Meningococcal B rLP2086 Vaccine in Adolescents
The purpose of this study is to evaluate the safety and immunogenicity of an investigational meningococcal B rLP2086 vaccine in adolescents aged 11 to 18 years old. › More
Epstein-Barr Virus (EBV)-Specific T Cells as Therapy for Relapsed/Refractory EBV-Positive Lymphomas (EPL)
This trial will use a new method of treating lymphoma using a therapy derived from a person's Killer T cells.These Killer T cells are taken from a person's blood and grown in a test tube to ... › More
GM-CSF Vaccinations After Allogeneic Blood Stem Cell Transplantation in Patients With Advanced Myeloid Malignancies
The purpose of this study is to investigate whether the addition of a vaccine after participants reduced intensity transplant will be safe and beneficial. The vaccine used in this ... › More
Intravenous Iron in Patients With Anaemia of Chronic Kidney Disease
The objective of this study is the evaluation of the efficacy and safety of intravenous iron sucrose in anaemic patients with chronic kidney disease not on › More
Pesticides in the Households of Healthy Volunteers and Young Patients With Leukaemia
Rationale: Learning about pesticides in the households of young patients with leukaemia and in the households of healthy volunteers may help scientists better understand ... › More
Iron Sucrose in Stage 3/4 Kidney Disease
One of the complications of late stage kidney disease is the development of a low red blood cell count (anaemia/low haemoglobin concentration). The Australian Commonwealth government limits ... › More
BMS-354825 in Patients With Chronic Accelerated, or Blast Phase Chronic Myelogenous Leukemia or Philadelphia Positive Acute Lymphoblastic Leukemia
The purpose of this clinical research study is to understand the safety and efficacy of BMS-354825 in patients with chronic, accelerated, or blast phase chronic myelogenous leukemia (CML) or ... › More
Safety and Efficacy of GS-9350-boosted Atazanavir Versus Ritonavir-boosted Atazanavir in HIV-1 Infected Adults
To evaluate the safety and efficacy of a regimen containing GS-9350-boosted atazanavir plus emtricitabine/tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus ... › More
The CANTATA-MSU Trial (CANagliflozin Treatment and Trial Analysis - Metformin and SUlphonylurea)
The purpose of this study is to evaluate the efficacy and safety of 2 different doses of canagliflozin compared with placebo in patients with type 2 diabetes mellitus who are receiving treatment with ... › More
Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission
The purposes of this study are to determine whether Carraguard® Gel can prevent the transmission of HIV when used during vaginal intercourse, and to confirm that the ... › More
Alemtuzumab to Treat Severe Aplastic Anaemia
This study will evaluate the safety and usefulness of a new immunosuppressive drug, alemtuzumab (Campath®), in patients with severe aplastic anemia (SAA). SAA is a rare and serious blood disorder ... › More
Study to Determine the Effect and Safety of an Oral Janus Kinase 2 (JAK2)-Inhibitor in Patients with Multiple Myeloma
The purpose of this study is to determine clinical efficacy and safety of INCB018424, a small molecule Janus kinase (JAK) inhibitor, in patients with refractory or relapsed multiple myeloma. › More
Treatment of Deficient Subclass or Anti-Polysaccharide Antibody
There is no consensus on the treatment of patients with recurrent infections and isolated immunoglobulin G (IgG)-subclass deficiency and/or selective antipolysaccharide antibody deficiency. ... › More
Treatment of Deficient Subclass or Anti-Polysaccharide Antibody Response (Subklasse)
There is no consensus on the treatment of patients with recurrent infections and isolated immunoglobulin G (IgG)-subclass deficiency and/or selective antipolysaccharide antibody deficiency. ... › More
Sirolimus Treatment in Patients With Autosomal Dominant Polycystic Kidney Disease: Renal Efficacy
Autosomal-Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary renal disease, characterised by the progressive development of fluid-filled cysts in the kidney leading to ... › More
Characteristics of Blood-Brain Barrier Permeability in Neurological Patients
The main goal of the present study is to challenge the hypothesis that blood-brain barrier disruption following brain injury increases the risk for long-term disability, development of brain ... › More
Sequestration of Platelets Prior to Bypass Reduces Bleeding After Cardiac Surgery
Excessive bleeding is common after cardiac surgery. This may result in patients receiving a blood transfusion or suffering the life-threatening complication of cardiac tamponade. Tamponade is when ... › More
